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PhD linkeropathies
This research project focusses on the study of molecular mechanisms underlying a group of inherited conditions caused by defects in five different enzymes necessary for proper assembly of the proteoglycan linker region and which are collectively called “linkeropathies”. In this project, knock-in zebrafish models will be generated and phenotypically characterized. Several genetic, transcriptomic, proteomic and glycomic approaches will be combined on relevant tissues to investigate and elucidate molecular pathways that are shared and/or different between these conditions to obtain a better understanding of the underlying disease mechanisms.